Advanced Pharmacology NURS-6521

*Write a 2- to 3-page paper that addresses the following:

*Explain how the factor you selected (older, geriatric adult) might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.
*Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples.
*Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements.

*To Prepare:

*Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.
*Review the case study assigned by your Instructor for this Assignment.
Select one of the following factors: genetics, gender, ethnicity, age, or behavior factors.
*Reflect on how your selected factor (older, geriatric adult) might influence the patient’s pharmacokinetic and pharmacodynamic processes.
*Consider how pharmacokinetic and pharmacodynamic processes changes might impact the patient’s recommended drug therapy.
*Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes.
*Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.


Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following:

Atenolol 12.5 mg daily

Doxazosin 8 mg daily

Hydralazine 10 mg qid

Sertraline 25 mg daily

Simvastatin 80 mg daily

*Please use the following resources for citations/references:

Rosenthal, L. D., & Burchum, J. R. (2021). Lehne’s pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.) St. Louis, MO: Elsevier.

Chapter 33, “Review of Hemodynamics” (pp. 285–289)

Chapter 37, “Diuretics” (pp. 290–296)

Chapter 38, “Drugs Acting on the Renin-Angiotensin-Aldosterone System” (pp. 297–307)

Chapter 39, “Calcium Channel Blockers” (pp. 308–312)

Chapter 40, “Vasodilators” (pp. 313–317)

Chapter 41, “Drugs for Hypertension” (pp. 316–324)

Chapter 42, “Drugs for Heart Failure” (pp. 325–336)

Chapter 43, “Antidysrhythmic Drugs” (pp. 337–348)

Chapter 44, “Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels” (pp. 349–363)

Chapter 45, “Drugs for Angina Pectoris” (pp. 364–371)

Chapter 46, “Anticoagulant and Antiplatelet Drugs” (pp. 372–388

Thank you, Peter!




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