IN EUKARYOTES, MIR-5 IS A MICRORNA WITH SEQUENCE COMPLEMENTARITY TO THE 3’UTR OF THE MRNA TRANSCRIPT ENCODED BY THE BIS GENE.
THE BIS GENE ENCODES FOR A PROTEIN THAT ACTS AS AN ALLOSTERIC INHIBITOR OF THE PROTEIN P101. THE P101 PROTEIN IS A DNA METHYLTRANSFERASE (DNMT) THAT FUNCTIONS TO METHYLATE DNA. 4. (2PTS) IN A BREAST CANCER CELL LINE, THE P101 PROTEIN IS ACTIVELEADING TO MISREGULATION OF GENE EXPRESSION. IN THESE BREAST CANCER CELLS WHICH OF THE FOLLOWING WOULD BE A CORRECT PREDICTION IN REGARDS TO MIR-5?
In eukaryotes, miR-5 is a microRNA with sequence complementarity to the 3’UTR of the mRNA transcript encoded by the BIS gene. The BIS gene encodes for a protein that acts as an allosteric inhibitor of the protein p101. The p101 protein is a DNA methyltransferase (DNMT) that functions to methylate DNA. 4. (2pts) In a breast cancer cell line, the p101 protein is activeleading to misregulation of gene expression. In these breast cancer cells which of the following would be a correct prediction in regards to miR-5?
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