PROKARYOTIC TOPOISOMERASE II, ALSO CALLED DNA GYRASE, IS SPECIFICALLY INHIBITED BY AN ANTIBIOTIC CALLED NOVOBIOCIN, WHICH BINDS TO THE Β SUBUNIT OF THE ENZYME.
THIS ANTIBIOTIC INHIBITS BACTERIAL DNA REPLICATION. WHAT DOES DNA GYRASE DO AND SUGGEST WHY A COMPOUND THAT INHIBITS THIS ENZYME WOULD BE AN EFFECTIVE ANTIBIOTIC.
Prokaryotic topoisomerase II, also called DNA gyrase, is specifically inhibited by an antibiotic called novobiocin, which binds to the β sub-unit of the enzyme. This antibiotic inhibits bacterial DNA replication. What does DNA gyrase do and suggest why a compound that inhibits this enzyme would be an effective antibiotic.