Traumatic Brain Injury (TBI) affects a wide variety of people nationwide. One constant does remain; the human condition suffers, both internally and externally.
The proposed study will review current literature and collective research models and data based on neural stem cell transplantation on injured brains and their positive outcomes; as well as, the facilitation of newly implemented procedures for localized drug therapy on their respective injury sites. Studies are primarily collected in controlled laboratory setting and modeled on mice for efficacy of desired treatment protocol as well as the clinical setting being modeled on Projectile Ballistics Brain Injury (PBBI) patients.
Pertinent research questions include: Is there sufficient clinical evidence to support that
the usage of neural progenitor cells expand neurogenesis activity within TBI structures of the
brain? As well as, What are the effects of neural stem cell transplants on endogenous neurogenesis
and neurobehavioral outcomes of PBBI patients? Data analysis was collected by reviewing TBI
literature under different treatment circumstances such as hypothermic, neurodegenerative,
immuno-compromised, behavioral standards, and lastly by quantifying the rate of neural cell
apoptosis within a 6 week period measured at 95% CI (α < p-value = 0.05). Overall the research
hopes to raise awareness of the achievable goals and positive steps that have been affiliated with
this specific type of research methodology.
PROBLEM STATEMENT
The general problem is represented with the figures provided by the CDCP in 2010;
about 2.5 million Emergency Department (ED) cases were associated with TBI; either presented
singly or in combination with another injury here in the United States (CDCP, 2014). TBI was a
diagnosis in more than 280,000 hospitals and of those cases 50,000 ended in death before and
while at the ED (CDCP, 2014). TBI’s rooted issues are based on scientific evidence that out of the
73 institutions currently focused on TBI research, only three are using neural stem cells to
promote neurogenesis in the brain and out of those three institutions, only two have a drug
approved by the FDA that increases glucose activity in injured bregma regions of the brain
(National Institute of Neurological Disorders and Stroke [NINDS], 2016). TBI is a major source
of death and disability here in the US; not only does it account for a large portion of ED care and
attention, treatment procedures and positive outcomes in today’s world of modern day medicine
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