An epidemiological investigation was begun on July 1, 2000 among a population of 1,000 individuals. Three individuals were found to have leukemia on July 1st. During
the ten-year follow-up period, five new cases of leukemia were diagnosed. Among the eight leukemia cases, four deaths occurred during the ten-year follow-up period.

Two additional individuals, neither of whom had leukemia, were lost to follow-up at some point during follow-up. None of the remaining 990 study participants became
ill, died, or were lost to follow-up during the follow-up period.
The diagram below indicates the experience of the 10 study participants, using the following symbols:
*

:case recognition (diagnosis of leukemia)

*<

:onset of leukemia was prior to start of study period

—-

:observation period during follow-up

X

:status at termination of observation (i.e., alive, dead, lost)

case

2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010

1


–*–
—–
—–
—–
—–
—–
—–
—–
—–
–X
alive
2


——
—–
–*–
—–
—–
—–
—–
—–
—–
–X
alive
3
*<–
——
——
—–
—–
—–
—–
—–
–X

dead
4


——
—–
—–
–X

lost
5


——
—–
—–
—–
—–
–*–
–X

dead
6


——
—–
—–
—–
—–
—–
—–
—–
–*–
–X
alive
7


–*–
—–
—–
–X

dead
8
*<–
——
——
—–
—–
—–
—–
—–
—–
—–
—–
–X
alive
9


——
—–
—–
—–
—–
—–
–X

lost
10
*<–
——
——
–X

dead
· What was the prevalence of leukemia on January 1, 2005?

· What was the cumulative incidence of leukemia during the 10-year follow-up period?

· What was the incidence rate of leukemia during the 10-year follow-up period?

· What was the case fatality rate during the 10-year follow-up period?

Mod 3

Question 1

For this problem, note the following chart:
Age Group
(in years)

% of Population in Age Group

Influenza Rate per 1,000 person-years

CITY A
CITY B
CITY C
Massachusetts
CITY A
CITY B
CITY C
YOUNG
40%


 

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